Hydroxyzine Withdrawal: Can Antihistamines be Abused?
First-generation antihistamines like hydroxyzine impact the central nervous system and, in rare cases, can cause dependence and hydroxyzine withdrawal. In 2021, an estimated 11 million hydroxyzine prescriptions were issued in the US. It is a drug considered low in the potential for addiction and abuse with minimal withdrawal side effects. However, new research has raised a few questions about the additive potential and safety of the medication due to its direct impact on the central nervous system.
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